Amfr CLIA Kit for Mouse(Mus musculus) | EIAab.comAmfr CLIA Kit for Mouse(Mus musculus)

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Amfr (Gene name),

E3 ubiquitin-protein ligase AMFR (Protein name ), AMFR_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Amfr;

Protein name:

E3 ubiquitin-protein ligase AMFR;

Alternative:

Autocrine motility factor receptor(AMF receptor);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with UBE2G2/UBC7 through a region distinct from the RING finger. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with RNF5.

Function:

E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol (By similarity). Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

643

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

643:

SSEDDGASER | LLPSEGTSSD | PVTLRRRMLA | AAAERRLQRQ | RTT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.34641

STRING:

10090.ENSMUSP00000052258

SMR:

Q9R049

Pfam:

PF02845

String:

Q9R049

KEGG:

mmu:23802

Uniprot:

Q9R049

FOR

ELISA Kit for Mouse E3 ubiquitin-protein ligase AMFR

Cat.:

E14974h

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MSDS:

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Packing:

96T

ELISA Kit for Mouse E3 ubiquitin-protein ligase AMFR

Cat.:

E14974m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase AMFR

Cat.:

U14974h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase AMFR

Cat.:

U14974m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase AMFR

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase AMFR

Protein for Mouse E3 ubiquitin-protein ligase AMFR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein."
Shimizu K. , Tani M. , Watanabe H. , Nagamachi Y. , Niinaka Y. , Shiroishi T. , Ohwada S. , Raz A. , Yokota J.
FEBS Lett.456:295-300(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Lung.
tissue: Testis.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: FVB/N.
tissue: Colon.
tissue: Mammary gland.
3.

"Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation."
Onishi Y. , Tsukada K. , Yokota J. , Raz A.
Clin. Exp. Metastasis20:51-58(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN METASTASIS
4.

"The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation."
Ballar P. , Shen Y. , Yang H. , Fang S.
J. Biol. Chem.281:35359-35368(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VCP IN THE VCP/P97-AMFR/GP78 COMPLEX;FUNCTION;SUBCELLULAR LOCATION
5.

"The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor."
Li G. , Zhao G. , Zhou X. , Schindelin H. , Lennarz W.J.
Proc. Natl. Acad. Sci. U.S.A.103:8348-8353(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NGLY1; PSMC1; SAKS1; RAD23B AND VCP
6.

"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain cortex.
7.

"Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508."
Morito D. , Hirao K. , Oda Y. , Hosokawa N. , Tokunaga F. , Cyr D.M. , Tanaka K. , Iwai K. , Nagata K.
Mol. Biol. Cell19:1328-1336(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF MISFOLDED PROTEINS;INTERACTION WITH RNF5
8.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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